Water does not flow across the tight junctions of MDCK cell epithelium

Proc Natl Acad Sci U S A. 1998 May 26;95(11):6526-30. doi: 10.1073/pnas.95.11.6526.

Abstract

Although it has been known for decades that the tight junctions of fluid-transporting epithelia are leaky to ions, it has not been possible to determine directly whether significant transjunctional water movement also occurs. An optical microscopic technique was developed for the direct visualization of the flow velocity profiles within the lateral intercellular spaces of a fluid-absorptive, cultured renal epithelium (MDCK) and used to determine the velocity of the fluid flow across the tight junction. The flow velocity within the lateral intercellular spaces fell to near zero adjacent to the tight junction, showing that significant transjunctional flow did not occur, even when transepithelial fluid movement was augmented by imposition of osmotic gradients.

MeSH terms

  • Animals
  • Biological Transport
  • Cell Line
  • Dogs
  • Epithelial Cells / metabolism*
  • Epithelial Cells / ultrastructure*
  • Osmolar Concentration
  • Tight Junctions / metabolism*
  • Water / metabolism*

Substances

  • Water