Bone marrow transplantation from a cadaveric donor

Bone Marrow Transplant. 1998 Apr;21(8):857-8. doi: 10.1038/sj.bmt.1701165.

Abstract

A 2.5-year-old girl with neurogenic Gaucher's disease was transplanted with donor bone marrow from her HLA-compatible 12-year-old brother whose marrow was harvested 30 min post-mortem, after he suffered a severe head and neck injury. The marrow was stored in liquid nitrogen for 30 days prior to infusion. The post-transplantation period was uneventful with good engraftment and no signs of graft-versus-host disease. Currently, 6 months post-allogeneic bone marrow transplantation (alloBMT), analysis of both bone marrow and blood samples by PCR documented only cells of donor origin. This case demonstrates the feasibility of cadaveric marrow as a source of donor cells. To our knowledge, this patient is the only survivor of alloBMT from a cadaveric donor.

Publication types

  • Case Reports

MeSH terms

  • Bone Marrow Transplantation*
  • Cadaver
  • Child, Preschool
  • Female
  • Gaucher Disease / therapy*
  • Humans