Rarity of surgical complications after postchemotherapy nephrectomy for nephroblastoma. Experience of the International Society of Paediatric Oncology-Trial and Study "SIOP-9". International Society of Paediatric Oncology Nephroblastoma Trial and Study Committee

Eur J Pediatr Surg. 1998 Apr;8(2):83-6. doi: 10.1055/s-2008-1071127.

Abstract

The aim of the study was to assess rates and types of nephrectomy-related complications in children nephrectomized for nephroblastoma after preoperative chemotherapy. Records of 598 Wilms' tumour patients registered in the International Society of Paediatric Oncology Trial & Study No. 9 (SIOP-9), and pretreated correctly according to the protocol with vincristine + actinomycin D +/- epirubicine or adriamycin prior to nephrectomy, were retrospectively reviewed. Forty-nine patients (8%), who suffered from 54 complications, were identified. Most frequent events were small-bowel occlusions (3.7%) and tumour ruptures (2.8%). Other complications were registered in 2.0% of cases. The low rate of nephrectomy complications and no deaths related to registered ones, are another argument for preoperative chemotherapy in Wilms' tumour patients.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Antibiotics, Antineoplastic / therapeutic use
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Chemotherapy, Adjuvant
  • Child
  • Child, Preschool
  • Dactinomycin / therapeutic use
  • Europe
  • Humans
  • Infant
  • Kidney Neoplasms / drug therapy
  • Kidney Neoplasms / surgery*
  • Nephrectomy / adverse effects*
  • Randomized Controlled Trials as Topic
  • Retrospective Studies
  • Vincristine / therapeutic use
  • Wilms Tumor / drug therapy
  • Wilms Tumor / surgery*

Substances

  • Antibiotics, Antineoplastic
  • Antineoplastic Agents, Phytogenic
  • Dactinomycin
  • Vincristine