Can reactive airways dysfunction syndrome (RADS) transform into occupational asthma due to "sensitisation" to isocyanates?

Thorax. 1998 Feb;53(2):152-3. doi: 10.1136/thx.53.2.152.

Abstract

The case history is described of a worker who presented with a history suggestive of reactive airways dysfunction syndrome which occurred after an acute high level inhalation of diphenylmethane diisocyanate. Further exposure at work, at a time when concentrations of isocyanates were no longer "irritant", suggested occupational asthma; this diagnosis was confirmed by a specific inhalation challenge test.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allergens / adverse effects*
  • Asthma / chemically induced*
  • Asthma / diagnosis
  • Bronchial Provocation Tests
  • Humans
  • Isocyanates / adverse effects*
  • Male
  • Middle Aged
  • Occupational Diseases / chemically induced*
  • Occupational Diseases / diagnosis
  • Occupational Exposure / adverse effects*
  • Respiratory Hypersensitivity / chemically induced*

Substances

  • Allergens
  • Isocyanates
  • 4,4'-diphenylmethane diisocyanate