Abstract
Strain TP-AO121 which produces a complex of novel tyrosine kinase inhibitors designated hibarimicins A, B, C, D and G was considered to be a new subspecies of Microbispora rosea, and the name, Microbispora rosea subsp. hibaria, was proposed. Hibarimicins A, B, C and D specifically inhibited the src tyrosine kinase activity without affecting protein kinase A or protein kinase C. They also showed in vitro anti-Gram-positive bacterial and antitumor activities. The molecular formulae of hibarimicins A, B, C, D and G were assigned to be C85H112O37, C85H112O37, C83H110O36, C85H112O38, and C85H112O39 respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actinomycetales / chemistry*
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Actinomycetales / classification
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Actinomycetales / genetics
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / isolation & purification
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Antibiotics, Antineoplastic / pharmacology
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Chemical Phenomena
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Chemistry, Physical
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DNA, Fungal / genetics
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology
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Fermentation
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Mice
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Nucleic Acid Hybridization
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Protein Kinase Inhibitors
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Signal Transduction / drug effects*
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Tumor Cells, Cultured
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src-Family Kinases / antagonists & inhibitors
Substances
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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DNA, Fungal
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Enzyme Inhibitors
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Protein Kinase Inhibitors
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src-Family Kinases