Abstract
The structure of hibarimicins A, B, C, D and G which are inhibitors for tyrosine specific protein kinase are determined using spectroscopic techniques. Hibarimicins described in this report consist of a common aglycon and six deoxyhexoses. The aglycon contains a highly oxidized naphtylnaphthoquinone as a chromophore. Among them, hibarimicin B was identical with angelmicin B.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actinomycetales / chemistry*
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Carbohydrates / chemistry
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Protein-Tyrosine Kinases / antagonists & inhibitors
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Signal Transduction / drug effects*
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Spectrometry, Mass, Fast Atom Bombardment
Substances
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Anti-Bacterial Agents
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Carbohydrates
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Enzyme Inhibitors
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Protein-Tyrosine Kinases