Comparative effects of malononitriloamide analogs of leflunomide on whole blood lymphocyte stimulation in humans, rhesus macaques, cats, dogs, and rats

Transplant Proc. 1998 Jun;30(4):1047-8. doi: 10.1016/s0041-1345(98)00145-6.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Alkynes
  • Animals
  • B-Lymphocytes / drug effects
  • B-Lymphocytes / immunology*
  • Cats
  • Dogs
  • Humans
  • Immunosuppressive Agents / pharmacology*
  • Isoxazoles / pharmacology*
  • Leflunomide
  • Lymphocyte Activation / drug effects*
  • Lymphocyte Activation / immunology
  • Macaca mulatta
  • Male
  • Nitriles / pharmacology*
  • Rats
  • Rats, Inbred Lew
  • Species Specificity
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology*

Substances

  • Alkynes
  • Immunosuppressive Agents
  • Isoxazoles
  • Nitriles
  • X 910279
  • 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide
  • Leflunomide