Estrogen-induced tumorigenesis in the pituitary gland of TGF-beta(+/-) knockout mice

N Shida; H Ikeda; T Yoshimoto; M Oshima; M M Taketo; I Miyoshi

doi:10.1016/s0925-4439(98)00024-6

Estrogen-induced tumorigenesis in the pituitary gland of TGF-beta(+/-) knockout mice

Biochim Biophys Acta. 1998 Jul 1;1407(1):79-83. doi: 10.1016/s0925-4439(98)00024-6.

Authors

N Shida¹, H Ikeda, T Yoshimoto, M Oshima, M M Taketo, I Miyoshi

Affiliation

¹ Department of Neurosurgery, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980, Japan.

PMID: 9639680
DOI: 10.1016/s0925-4439(98)00024-6

Abstract

Transforming growth factor (TGF)-beta receptor type II gene (Tgfbr2) knockout and wild type mice underwent chronic estrogen exposure using estradiol pellets. Histological examination of the pituitary glands found 38 adenomas in 14 Tgfbr2(+/-) mice but only one tumor in ten wild type mice. Pituitary tumorigenesis is greatly accelerated in Tgfbr2(+/-) mice by estrogen treatment.

MeSH terms

Adenoma / chemically induced*
Adenoma / pathology
Animals
Estradiol / pharmacology*
Heterozygote
Mice
Mice, Knockout
Pituitary Neoplasms / chemically induced*
Pituitary Neoplasms / pathology
Protein Serine-Threonine Kinases
Receptor, Transforming Growth Factor-beta Type II
Receptors, Transforming Growth Factor beta / analysis
Receptors, Transforming Growth Factor beta / genetics*

Substances

Receptors, Transforming Growth Factor beta
Estradiol
Protein Serine-Threonine Kinases
Receptor, Transforming Growth Factor-beta Type II