Abstract
Three new cytotoxic cembranoid diterpenes, sinuflexolide (1), dihydrosinuflexolide (2), and sinuflexibilin (3), have been isolated from the soft coral Sinularia flexibilis. The structures of compounds 1-3 were determined by spectral and X-ray crystallographic analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Cnidaria / chemistry*
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Conformation
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Diterpenes
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dihydrosinuflexolide
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sinuflexibilin
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sinuflexolide