Isolation of 2-(3'-bromo-4'-hydroxyphenol)ethanamine from the New Zealand ascidian Cnemidocarpa bicornuta

B S Lindsay; C N Battershill; B R Copp

doi:10.1021/np980052q

Isolation of 2-(3'-bromo-4'-hydroxyphenol)ethanamine from the New Zealand ascidian Cnemidocarpa bicornuta

J Nat Prod. 1998 Jun 26;61(6):857-8. doi: 10.1021/np980052q.

Authors

B S Lindsay¹, C N Battershill, B R Copp

Affiliation

¹ Department of Chemistry, University of Auckland, Private Bag 92019, Auckland, New Zealand.

PMID: 9644087
DOI: 10.1021/np980052q

Abstract

From the ascidian Cnemidocarpa bicornuta, 2-(3'-bromo-4'-hydroxyphenol)ethanamine (3'-bromotyramine) (1) has been isolated along with the previously reported sponge metabolite, 1,3-dimethylisoguanine. The structure of 1 was confirmed by synthesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Bacteria / drug effects
Candida albicans
Chromatography, High Pressure Liquid
Leukemia P388 / drug therapy
Magnetic Resonance Spectroscopy
Mass Spectrometry
Mice
Microbial Sensitivity Tests
New Zealand
Rats
Spectrophotometry, Ultraviolet
Tyramine / analogs & derivatives*
Tyramine / isolation & purification
Tyramine / pharmacology
Urochordata / chemistry*

Substances

2-(3'-bromo-4'-hydroxyphenol)ethanamine
Antineoplastic Agents
Tyramine