Henoch-Schoenlein purpura and acute interstitial nephritis after intravenous vancomycin administration in a patient with a staphylococcal infection

Scand J Rheumatol. 1998;27(3):233-5. doi: 10.1080/030097498440886.

Abstract

We describe a case of Henoch-Schoenlein purpura, associated with oliguric acute renal failure due to acute interstitial nephritis histologically proven, in a patient with a staphylococcal chest infection. The clinical syndrome appeared twice after vancomycin administration and yielded on the withdrawal of the drug. As pathogenetic mechanism we propose an anaphylactoid reaction either to vancomycin or to a staphylococcal glycoprotein released after breakdown of the microbial cells caused by vancomycin.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • Anti-Bacterial Agents / adverse effects*
  • Glomerular Mesangium / pathology
  • Humans
  • IgA Vasculitis / chemically induced*
  • IgA Vasculitis / pathology
  • Injections, Intravenous
  • Male
  • Nephritis, Interstitial / chemically induced*
  • Nephritis, Interstitial / pathology
  • Skin / pathology
  • Staphylococcal Infections / drug therapy*
  • Vancomycin / adverse effects*

Substances

  • Anti-Bacterial Agents
  • Vancomycin