Abstract
A dog was euthanatized because of progressive neurological signs. Histologically, a nonsuppurative meningoencephalitis was found. By immunohistochemistry, in situ hybridization, and nested PCR procedures, Borna disease virus (BDV) antigen and BDV-specific RNA were demonstrated in brain tissues of the dog. The nucleotide sequence of the PCR product showed 94 to 98% homology to published BDV sequences. This is the first description of Borna disease in a dog.
MeSH terms
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Animals
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Antigens, Viral / analysis
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Base Sequence
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Borna Disease / virology*
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Borna disease virus / classification
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Borna disease virus / isolation & purification*
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Brain / ultrastructure
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Brain / virology
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Dog Diseases / virology*
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Dogs
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Female
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Immunohistochemistry
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In Situ Hybridization
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Meningoencephalitis / veterinary*
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Meningoencephalitis / virology
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Molecular Sequence Data
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Polymerase Chain Reaction / methods
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RNA, Viral / analysis
Substances
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Antigens, Viral
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RNA, Viral
Associated data
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GENBANK/AF054275
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GENBANK/AF054276
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GENBANK/AF054277