Primary nail invasion by Candida is uncommon and almost exclusively seen in patients with an impaired immune function. The appearance of Candida onychomycosis in an adult who is not under immunosuppressive treatment always requires a laboratory evaluation of the immunologic function including HIV assays. We report 2 cases of distal subungual onychomycosis due to Candida sp. in HIV. In one of our patients, the diagnosis of Candida onychomycosis preceded the diagnosis of advanced HIV infection. In both of our patients treatment with systemic antifungals produced complete cure of Candida onychomycosis and the 1 year follow-up did not reveal any relapse of the onychomycosis.