Abstract
We show that the fraction of proliferating CD4+ lymphocytes is similar in HIV-infected subjects in the early stage of disease and in HIV-negative subjects, whereas the fraction of proliferating CD8+ lymphocytes is increased 6.8-fold in HIV-infected subjects. After initiation of antiviral therapy, there is a late increase in proliferating CD4+ T cells associated with the restoration of CD4+ T-cell counts. These results provide strong support for the idea of limited CD4+ T-cell renewal in the early stage of HIV infection and indicate that after effective suppression of virus replication, the mechanisms of CD4+ T-cell production are still functional in early HIV infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Anti-HIV Agents / therapeutic use*
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CD4-CD8 Ratio
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CD4-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / immunology
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Carbamates
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Cell Division
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Dideoxynucleosides / therapeutic use*
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Drug Therapy, Combination
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Female
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Furans
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HIV Infections / drug therapy*
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HIV Infections / immunology*
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HIV Protease Inhibitors / therapeutic use*
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Humans
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Ki-67 Antigen / metabolism
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Lymph Nodes / metabolism
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Male
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Middle Aged
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Reverse Transcriptase Inhibitors / therapeutic use*
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Sulfonamides / therapeutic use*
Substances
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Anti-HIV Agents
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Carbamates
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Dideoxynucleosides
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Furans
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HIV Protease Inhibitors
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Ki-67 Antigen
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Reverse Transcriptase Inhibitors
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Sulfonamides
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amprenavir
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abacavir