Homology-based fold predictions for Mycoplasma genitalium proteins

J Mol Biol. 1998 Jul 17;280(3):323-6. doi: 10.1006/jmbi.1998.1884.

Abstract

Homology search techniques based on the iterative PSI-BLAST method in combination with various filters for low sequence complexity are applied to assign folds to all Mycoplasma genitalium proteins. The resulting procedure (implemented as a web server) is able to predict at least one domain in 37% of these proteins automatically, with an estimated accuracy higher than 98%. Taking structural features such as coiled coil or transmembrane regions aside, folds can be assigned to more than half of the globular proteins in a bacterium just by iterative sequence comparison.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / chemistry*
  • Mycoplasma / chemistry*
  • Protein Conformation
  • Protein Folding*
  • Sequence Homology

Substances

  • Bacterial Proteins