Abstract
The methods outlined in Subheading 3. provide a logical sequence of assays with which to evaluate the biochemical and biological properties of potential FPTase inhibitors. The clinical predictability of these assays must await the evaluation of one or more of these compounds in humans.
MeSH terms
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Alkyl and Aryl Transferases / antagonists & inhibitors*
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Animals
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Genes, ras
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Humans
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Mice
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Mice, Nude
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Mice, Transgenic
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Molecular Biology / methods
Substances
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Enzyme Inhibitors
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Alkyl and Aryl Transferases
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p21(ras) farnesyl-protein transferase