Long-term selective IgG immuno-adsorption improves Rasmussen's encephalitis

C Antozzi; T Granata; N Aurisano; G Zardini; P Confalonieri; G Airaghi; R Mantegazza; R Spreafico

doi:10.1212/wnl.51.1.302

Long-term selective IgG immuno-adsorption improves Rasmussen's encephalitis

Neurology. 1998 Jul;51(1):302-5. doi: 10.1212/wnl.51.1.302.

Authors

C Antozzi¹, T Granata, N Aurisano, G Zardini, P Confalonieri, G Airaghi, R Mantegazza, R Spreafico

Affiliation

¹ Neuromuscular Research Department, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy.

PMID: 9674829
DOI: 10.1212/wnl.51.1.302

Abstract

We report that long-term selective immunoglobulin G immunoadsorption by protein A (PAI) improved seizure frequency and neuropsychological deficits in a 16-year-old patient with severe treatment-resistant Rasmussen's encephalitis (RE). Clinical improvement correlated with reduction of antiglutamate receptor 3 antibodies. The efficacy of PAI in our patient supports the autoimmune hypothesis of RE and suggests its application to avoid, or at least delay, functional hemispherectomy in selected cases.

Publication types

Case Reports

MeSH terms

Adolescent
Autoantibodies / isolation & purification*
Encephalitis / immunology
Encephalitis / therapy*
Epilepsia Partialis Continua / immunology
Epilepsia Partialis Continua / therapy*
Female
Humans
Immunoglobulin G / isolation & purification*
Immunosorbents
Language
Neuropsychological Tests
Receptors, Metabotropic Glutamate / immunology
Staphylococcal Protein A / immunology

Substances

Autoantibodies
Immunoglobulin G
Immunosorbents
Receptors, Metabotropic Glutamate
Staphylococcal Protein A
metabotropic glutamate receptor 3