Abstract
Using a bioassay-directed fractionation method, three new compounds, including an aporphine alkaloid, cassyformine (4); an oxoaporphine alkaloid, filiformine (8), and a lignan, (+)-diasyringaresinol (10), along with 14 known compounds, were further isolated and characterized from the MeOH extract of the fresh herbs of Cassytha filiformis. Among the isolates of this plant, cathafiline (1), cathaformine (2), actinodaphnine (3), N-methylactinodaphnine (5), predicentrine (6), and ocoteine (7) exhibited significant antiplatelet aggregation activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Biological Assay
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Carbohydrate Sequence
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Sequence Data
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Plant Extracts / analysis
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Plants, Medicinal / chemistry*
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Platelet Aggregation Inhibitors / isolation & purification*
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Platelet Aggregation Inhibitors / pharmacology
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Rabbits
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Taiwan
Substances
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Alkaloids
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Plant Extracts
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Platelet Aggregation Inhibitors