Synthetic study on a novel Asn-linked core structure: synthesis of a pentasaccharide alpha-D-Man-(1-->3)-[alpha-D-Man-(1-->6)]-beta-D-Man-(1-->4)- [beta-D-GlcNAc-(1-->60]-beta-D-GlcNAc-->OMp

Carbohydr Res. 1998 Feb;306(4):539-44. doi: 10.1016/s0008-6215(98)00031-7.

Abstract

Synthesis of a pentasaccharide alpha-D-Man-(1-->3)-[alpha-D-Man-(1-->6)] -beta-D-Man-(1-->4)-beta-D-GlcNac(1-->6)]beta-GlcNAc-->Omp (2) is described. A comparison between the 1H NMR data of 2 and those of a novel Asn-linked core structure 1 containing a new GlcNAc residue suggests an alpha-D-configuration for the new linkage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylglucosamine / chemistry
  • Carbohydrate Sequence
  • Glycoproteins / chemistry
  • Isomerism
  • Molecular Sequence Data
  • Nuclear Magnetic Resonance, Biomolecular
  • Oligosaccharides / chemical synthesis*

Substances

  • Glycoproteins
  • Oligosaccharides
  • Acetylglucosamine