Morphological variants in keratoconus: anatomical observation or aetiologically significant?

Aust N Z J Ophthalmol. 1998 May:26 Suppl 1:S68-70. doi: 10.1111/j.1442-9071.1998.tb01378.x.

Abstract

Purpose: Two morphological cone variants are identified in keratoconus; nipple and oval. The present study was designed to assess the impact of aetiological factors on cone morphology.

Methods: As part of a prospective controlled study, keratoconic subjects from a suburban practice (n = 89) underwent videokeratograph examination and completed a questionnaire detailing aetiological factors.

Results: Comparison of 95% confidence limits (CL; bootstrap method) for apical power between the two cone morphology groups showed no statistical significance. Oval cones were located at a greater eccentricity than nipple cones, as their definitions suggest. Associations between aetiological factors examined and the morphology of the cone were not significant (bootstrapped 95% CL).

Conclusion: Despite the suggestion of morphological variants in keratoconus, the results of the present study suggest a common cone aetiology.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Cornea / pathology*
  • Cornea / surgery
  • Corneal Topography
  • Humans
  • Keratoconus / etiology
  • Keratoconus / pathology*
  • Keratoconus / surgery
  • Keratoplasty, Penetrating
  • Prospective Studies
  • Risk Factors
  • Surveys and Questionnaires