Abstract
Subcellular targeting of the cAMP-dependent protein kinase is achieved, in part, through association with A-kinase anchoring proteins (AKAPs). Recent evidence suggests that specific AKAPs direct the kinase to submembrane sites to facilitate phosphorylation and modulation of a variety of ion channels. A new membrane-anchored AKAP targets cAMP-dependent protein kinase to calcium channels and enhances their regulation in multiple cell types.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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A Kinase Anchor Proteins
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Adaptor Proteins, Signal Transducing*
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Calcium Channels / physiology*
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Calcium Channels, L-Type
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Carrier Proteins / metabolism*
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Cyclic AMP / metabolism*
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Cyclic AMP-Dependent Protein Kinases / metabolism*
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Ion Channel Gating / physiology*
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Membrane Proteins / metabolism*
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Receptors, Glutamate / physiology
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Signal Transduction / physiology
Substances
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A Kinase Anchor Proteins
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AKAP7 protein, human
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Adaptor Proteins, Signal Transducing
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Calcium Channels
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Calcium Channels, L-Type
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Carrier Proteins
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Membrane Proteins
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Receptors, Glutamate
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Cyclic AMP
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Cyclic AMP-Dependent Protein Kinases