Abstract
Viral replication was inhibited in a dose-dependent manner after administration of the phosphorothioate oligonucleotide TTGGGGTT (ISIS 5320) to human immunodeficiency virus type 1 (HIV-1)-infected SCID-hu Thy/Liv mice. Potent in vivo antiviral activity was observed against the T-cell-tropic molecular clone NL4-3; the agent was found to have weak activity against one primary HIV-1 isolate, and the agent was inactive against a second primary isolate.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / drug therapy
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Animals
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Anti-HIV Agents / pharmacology*
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Disease Models, Animal
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Dose-Response Relationship, Drug
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HIV-1 / drug effects*
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Humans
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Mice
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Mice, SCID
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Oligodeoxyribonucleotides / pharmacology*
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T-Lymphocytes / transplantation
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Thionucleotides / pharmacology*
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Virus Replication / drug effects
Substances
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Anti-HIV Agents
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Oligodeoxyribonucleotides
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Thionucleotides
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oligonucleotide 5320