Abstract
Bovine herpesvirus 1 (BHV-1) induces apoptotic cell death in bovine peripheral blood mononuclear cells and B-lymphoma cells. Using a BHV-1 glycoprotein H null mutant, we have demonstrated that although penetration of BHV-1 is not required, attachment of BHV-1 viral particles is essential for the induction of apoptosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apoptosis*
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Cattle
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Cell Line
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Cells, Cultured
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DNA Fragmentation
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Gene Deletion
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Heparin / pharmacology
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Herpesvirus 1, Bovine / metabolism*
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Herpesvirus 1, Bovine / physiology
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Leukocytes, Mononuclear / cytology
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Tumor Cells, Cultured
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Viral Proteins / genetics
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Viral Proteins / physiology*
Substances
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Viral Proteins
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bovine herpesvirus type-1 glycoproteins
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Heparin