Two fetal deaths associated with maternal sepsis and with thrombosis of the intervillous space of the placenta

Placenta. 1998 Jul-Aug;19(5-6):385-9. doi: 10.1016/s0143-4004(98)90078-9.

Abstract

The placental pathology in two second trimester fetal losses associated with mild maternal disseminated intravascular coagulation are reported. Case one had a dental abscess, a leukocytosis of 36300 white blood cells/m, and evidence of mild consumptive coagulopathy at 20 weeks. Case two had septic findings including disseminated intravascular thrombosis associated with pyelonephritis. The placentae had extensive intervillous thrombosis at the periphery of spiral arterial flow. It is hypothesized that in mild disseminated intravascular coagulation, the trophoblast inhibits fibrinolysis, favouring thrombosis perhaps due to production of plasminogen activator inhibitor.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chorionic Villi / blood supply*
  • Chorionic Villi / pathology
  • Disseminated Intravascular Coagulation / complications*
  • Female
  • Fetal Death / etiology*
  • Humans
  • Leukocytosis / complications
  • Periodontal Abscess / complications
  • Pregnancy
  • Pregnancy Complications, Hematologic*
  • Pregnancy Complications, Infectious*
  • Pyelonephritis / complications
  • Thrombosis / complications*
  • Thrombosis / pathology