A new fashion of prostate transperineal biopsy (seven cores from each lobe) is described, in order to evaluate a potential increase of prostate cancer detection rate. From June 1996 to PSA. April 1997, 247 patients underwent transperineal biopsy for an abnormal DRE and/or elevated In addition to apex, base and lateral peripheral samples, two more were obtained from middle-lateral peripheral zone and tow more from transition zone of each lobe of the prostate. In 14 patients (13.1%) carcinoma was detected in the additional samples only. This new biopsy fashion seems to be safe and more accurate than sextant biopsy for a significant percentage of cancer that otherwise would have been missed.