Is the medial globus pallidus a site for stimulation or lesioning in the treatment of Parkinson's disease?

Stereotact Funct Neurosurg. 1997;69(1-4 Pt 2):62-8. doi: 10.1159/000099853.

Abstract

After the encouraging report on bilateral pallidal stimulation by Siegfried in 1994, we started this procedure in 1995 and will report our experience in 6 patients with a mean follow-up of 1 year. In contrast to the good results of pallidotomy reported in the literature improving the 'on' symptoms as dyskinesias as well as 'off' symptoms such as rigidity, bradykinesia and on-off fluctuations, our results indicate that pallidal stimulation improves the 'off' symptoms only to a minor extent and L-dopa-induced dyskinesias remain the main indication. Considering the overall functional outcome, the question arises whether the medial globus pallidus should be lesioned or stimulated.

MeSH terms

  • Aged
  • Electric Stimulation Therapy*
  • Electrodes, Implanted
  • Follow-Up Studies
  • Functional Laterality / physiology
  • Globus Pallidus / anatomy & histology
  • Globus Pallidus / physiology*
  • Globus Pallidus / surgery*
  • Humans
  • Magnetic Resonance Imaging
  • Microelectrodes
  • Middle Aged
  • Monitoring, Intraoperative
  • Parkinson Disease / surgery*
  • Parkinson Disease / therapy*
  • Stereotaxic Techniques
  • Treatment Outcome