Abstract
We report the cases of two patients fulfilling DSM-IV criteria for schizophrenia, who developed a marked depressive symptomatology in the first period of a treatment with clozapine, and were treated successfully with serotonergic drugs (paroxetine, clomipramine). The AA. discuss the possible neurochemical determinants and implications of these clinical observations.
MeSH terms
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Adult
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Antidepressive Agents, Second-Generation / therapeutic use
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Antidepressive Agents, Tricyclic / therapeutic use
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Antipsychotic Agents / adverse effects*
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Antipsychotic Agents / therapeutic use*
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Clomipramine / therapeutic use
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Clozapine / adverse effects*
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Clozapine / therapeutic use*
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Depression / chemically induced*
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Depression / drug therapy
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Female
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Humans
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Male
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Middle Aged
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Paroxetine / therapeutic use
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Schizophrenia / drug therapy*
Substances
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Antidepressive Agents, Second-Generation
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Antidepressive Agents, Tricyclic
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Antipsychotic Agents
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Paroxetine
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Clozapine
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Clomipramine