Aims: Risk factors for progression of atherosclerosis in non-grafted coronary arteries were examined in a prospective 5-year follow-up study of 228 consecutive coronary artery bypass surgery patients, with the main emphasis on insulin resistance syndrome.
Methods and results: Serum lipids and lipoproteins were measured pre-operatively and 1, 2, 3 and 5 years after surgery; and a baseline oral glucose tolerance test with plasma insulin determinations was performed pre-operatively. Progression of atherosclerosis was assessed by means of computer-based quantitative coronary angiography. Compared to subjects without progression, the patients with progression of atherosclerotic lesions had a higher body mass index both at baseline (P = 0.022) and at 5 years (P = 0.007), were more often treated for hypertension at baseline (P = 0.008) and at 5 years (P = 0.012), used diuretics more often during the follow-up period (P = 0.002), had a larger blood glucose area under the curve (P = 0.015) and a lower insulin sensitivity index (P = 0.006) in the baseline oral glucose tolerance test, had a higher serum total cholesterol concentration at baseline (P = 0.044), and a higher serum triglyceride concentration (P = 0.005) during the whole follow-up period. Clustering of the components of insulin resistance syndrome at baseline was more frequently found in patients with progression of atherosclerotic lesions than in patients without progression (P = 0.025). For example, for patients with < or = 1 component, the risk of progression was 17%, while for patients with > or = 5 components the risk was 67%. As compared to the other patients, those with new atherosclerotic lesions had a lower insulin sensitivity index at baseline (P = 0.033), and a lower serum high density lipoprotein cholesterol concentration during the follow-up period (P = 0.033).
Conclusion: In addition to high serum cholesterol, the components of the insulin resistance syndrome are associated with progression of atherosclerosis in non-grafted coronary arteries 5 years after coronary artery bypass surgery.