Expression of human transferrin receptor is controlled by a gene on chromosome 3: assignment using species specificity of a monoclonal antibody

P N Goodfellow; G Banting; R Sutherland; M Greaves; E Solomon; S Povey

doi:10.1007/BF01538677

Expression of human transferrin receptor is controlled by a gene on chromosome 3: assignment using species specificity of a monoclonal antibody

Somatic Cell Genet. 1982 Mar;8(2):197-206. doi: 10.1007/BF01538677.

Authors

P N Goodfellow¹, G Banting, R Sutherland, M Greaves, E Solomon, S Povey

Affiliation

¹ Imperial Cancer Research Fund, London, U.K.

PMID: 9732749
DOI: 10.1007/BF01538677

Abstract

The monoclonal antibody OKT-9 has been shown to recognize the human transferrin receptor. We have exploited the species specificity of OKT-9 to map a gene controlling human transferrin receptor expression to chromosome 3, using human-mouse somatic cell hybrids. The gene for the human transferrin receptor and the gene controlling transferrin expression may be linked in humans.

MeSH terms

Animals
Antibodies, Monoclonal / immunology*
Chromosome Mapping*
Chromosomes, Human, Pair 3*
Cross Reactions
Gene Expression Regulation
Humans
Iodine Radioisotopes
Mice
Precipitin Tests
Radioimmunoassay
Receptors, Transferrin / genetics*
Receptors, Transferrin / immunology*
Species Specificity

Substances

Antibodies, Monoclonal
Iodine Radioisotopes
Receptors, Transferrin