Jarisch-Herxheimer reaction complicating the treatment of chronic Q fever endocarditis: elevated TNFalpha and IL-6 serum levels

J Infect. 1998 Jul;37(1):83-4. doi: 10.1016/s0163-4453(98)91120-3.

Abstract

Jarisch-Herxheimer reaction (J-HR) is an acute febrile reaction which may complicate the initiation of an effective treatment against infections due to intracellular micro-organisms. We report a case of J-HR complicating treatment of chronic Q fever endocarditis with demonstration of elevated serum cytokine concentrations.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use
  • Anti-Infective Agents / adverse effects
  • Anti-Infective Agents / therapeutic use
  • Chronic Disease
  • Coxiella burnetii / isolation & purification*
  • Doxycycline / adverse effects
  • Doxycycline / therapeutic use
  • Drug Hypersensitivity*
  • Endocarditis, Bacterial / drug therapy*
  • Endocarditis, Bacterial / immunology
  • Endocarditis, Bacterial / microbiology*
  • Humans
  • Interleukin-6 / blood
  • Male
  • Middle Aged
  • Ofloxacin / adverse effects
  • Ofloxacin / therapeutic use
  • Q Fever / drug therapy*
  • Q Fever / immunology
  • Q Fever / microbiology
  • Time Factors
  • Tumor Necrosis Factor-alpha / analysis

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • Ofloxacin
  • Doxycycline