Antimalarial activities of polyhydroxyphenyl and hydroxamic acid derivatives

K P Holland; H L Elford; V Bracchi; C G Annis; S M Schuster; D Chakrabarti

doi:10.1128/AAC.42.9.2456

Antimalarial activities of polyhydroxyphenyl and hydroxamic acid derivatives

Antimicrob Agents Chemother. 1998 Sep;42(9):2456-8. doi: 10.1128/AAC.42.9.2456.

Authors

K P Holland¹, H L Elford, V Bracchi, C G Annis, S M Schuster, D Chakrabarti

Affiliation

¹ Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida 32611, USA.

Abstract

Several known mammalian ribonucleotide reductase inhibitors featuring a polyhydroxyphenyl and/or hydroxamate moiety as the active group were screened for potency in inhibiting growth of the malaria parasite Plasmodium falciparum. Compounds containing a 2,3- or 3,4-dihydroxyphenyl group as well as benzohydroxamate appear to be the most effective inhibitors of the malaria parasite.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Antimalarials / pharmacology*
Hydroxamic Acids / pharmacology*
Hydroxyurea / pharmacology
Plasmodium falciparum / drug effects
Ribonucleotide Reductases / antagonists & inhibitors*
Structure-Activity Relationship

Substances

Antimalarials
Hydroxamic Acids
Ribonucleotide Reductases
Hydroxyurea

Abstract

Publication types

MeSH terms

Substances

Grants and funding