Abstract
The bioassay-guided fractionation of Taraxacum platycarpum (Compositae) extract led to the isolation of a desacetylmatricarin (1) as an active principle responsible for the anti-allergic property. It showed a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner and the IC50 was 7.5 microM. Two structurally related guaianolide sesquiterpenes, achillin and leucodin, were also examined and their IC50 values were determined as 100 microM and 80 microM, respectively.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylglucosaminidase / metabolism
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Animals
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Anti-Allergic Agents / chemistry*
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Anti-Allergic Agents / isolation & purification
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Anti-Allergic Agents / pharmacology
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Cytoplasmic Granules / drug effects
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Cytoplasmic Granules / physiology
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Lactones / chemistry*
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Lactones / isolation & purification
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Lactones / pharmacology
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Leukemia, Basophilic, Acute
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Plant Extracts / chemistry*
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Plants, Medicinal*
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Rats
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
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Tumor Cells, Cultured
Substances
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Anti-Allergic Agents
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Lactones
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Plant Extracts
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Sesquiterpenes
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hydroxyachillin
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Acetylglucosaminidase