Cytopathology is no longer simply a screening modality limited to the "Pap mills" of yore. The news in cervicovaginal cytology is automation. The news in FNA cytology is the application of molecular techniques. Whether it is the detection of specific proteins/antigens for definitive diagnoses/treatment guidance in immunotherapy, or it is "reading nucleic acids," the cytopathologist of the future will be called upon to gather and report more detailed and precise information. As we develop methods for extrapolating the secrets previously locked within the individual cells, it becomes evident that the cells were talking all along, we just did not know how to listen.