Hair cells in mammalian utricles

Otolaryngol Head Neck Surg. 1998 Sep;119(3):172-81. doi: 10.1016/S0194-5998(98)70052-X.

Abstract

Two morphological classes of mechanosensory cells have been described in the vestibular organs of mammals, birds, and reptiles: type I and type II hair cells. Type II hair cells resemble hair cells in other organs in that they receive bouton terminals from primary afferent neurons. In contrast, type I hair cells are enveloped by large cuplike afferent terminals called calyces. Type I and II cells differ in other morphological respects: cell shape, hair bundle properties, and more subtle ultrastructural features. Understanding the functional significance of these strikingly different morphological features has proved to be a challenge. Experiments that correlated the response properties of primary vestibular afferents with the morphologies of their afferent terminals suggested that the synapse between the type I hair cell and calyx ending is lower gain than that between a type II hair cell and a bouton ending. Recently, patch-clamp experiments on isolated hair cells have revealed that type I hair cells from diverse species have a large potassium conductance that is activated at the resting potential. As a consequence, the voltage responses generated by the type I hair cells in response to injected currents are smaller than those generated by type II hair cells. This may contribute to the lower gain of type I inputs to primary afferent neurons. Studies of neonatal mouse utricles show that the type I-specific potassium conductance is not present at birth but emerges during the first postnatal week, a period of morphological differentiation of type I and type II hair cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Hair Cells, Vestibular / anatomy & histology
  • Hair Cells, Vestibular / physiology*
  • In Vitro Techniques
  • Ion Channels / physiology
  • Mice
  • Neural Conduction
  • Neurons, Afferent / cytology
  • Neurons, Afferent / physiology
  • Neurons, Efferent / cytology
  • Neurons, Efferent / physiology
  • Rats
  • Saccule and Utricle / anatomy & histology
  • Saccule and Utricle / innervation*

Substances

  • Ion Channels