Abstract
A series of novel N-(4,5-dihydroimidazol-2-yl)-1,3-dihydrobenzimidazole derivatives 2a-d, 3a-d and 4a-p were prepared and their structure was determined by IR and NMR spectroscopic data as well as X-ray analysis of carbonitrile 2a. The compounds were studied as potential inhibitors of the human blood platelet aggregation induced by adrenaline or ADP. Compounds of type 3 proved efficacious for the reduction of arterial blood pressure upon intravenous administration to normotensive rats.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzimidazoles / chemical synthesis
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Benzimidazoles / chemistry*
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Benzimidazoles / pharmacology
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Blood Pressure / drug effects
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Heart Rate / drug effects
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Humans
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Male
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Platelet Aggregation Inhibitors / chemical synthesis
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Platelet Aggregation Inhibitors / chemistry*
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Platelet Aggregation Inhibitors / pharmacology
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Rats
Substances
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Benzimidazoles
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Platelet Aggregation Inhibitors