Abstract
By animal to animal passage in rhesus and pig-tailed macaques, we developed a rhesus model of HIV-1 disease in humans. Rhesus macaques infected with a cell-free stock of SHIVKU-2 developed CD4+ T cell loss, primary lentiviral encephalitis and pneumonia, and AIDS. Six of nine rhesus macaques died within eight months post-inoculation, while the remaining three are at five, five, and eight months post-inoculation, respectively. Animals infected by either mucosal or parenteral routes of infection had a similar course of infection.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / immunology
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Acquired Immunodeficiency Syndrome / physiopathology*
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Animals
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CD4 Lymphocyte Count
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CD4-Positive T-Lymphocytes / immunology*
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Cell Line
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Flow Cytometry
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Genes, env
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Genes, rev
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Genes, tat
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Genes, vpu
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HIV-1 / genetics*
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HIV-1 / immunology
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HIV-1 / pathogenicity
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Humans
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Immune Tolerance
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Macaca mulatta
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Reassortant Viruses / genetics*
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Reassortant Viruses / immunology
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Reassortant Viruses / pathogenicity
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Simian Immunodeficiency Virus / genetics*
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Simian Immunodeficiency Virus / immunology
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Simian Immunodeficiency Virus / pathogenicity
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T-Lymphocytes / virology
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Virulence