De novo design and discovery of cyclic HIV protease inhibitors capable of displacing the active-site structural water molecule

Pharm Biotechnol. 1998:11:257-84. doi: 10.1007/0-306-47384-4_12.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Azepines / chemical synthesis
  • Binding Sites
  • Drug Design*
  • HIV Protease / chemistry
  • HIV Protease Inhibitors / chemical synthesis*
  • HIV Protease Inhibitors / pharmacokinetics
  • Humans
  • Molecular Conformation
  • Urea / analogs & derivatives
  • Urea / chemical synthesis

Substances

  • Azepines
  • HIV Protease Inhibitors
  • Urea
  • HIV Protease
  • DMP 323
  • DMP 450