White blood cell count is a poor predictor of severity of disease in the diagnosis of appendicitis

Am Surg. 1998 Oct;64(10):983-5.

Abstract

The white blood cell (WBC) count is considered to be a useful test in the diagnosis of appendicitis. The purpose of this study was to examine the clinical features of patients with normal WBC appendicitis and also to determine whether a higher WBC count correlates with a more advanced stage of appendicitis. Patients with pathologically confirmed appendicitis from January 1989 to December 1994 were included in the study (n = 1919). The age, gender, temperature, length of hospital stay, and severity of disease (1 = acute appendicitis; 2 = gangrenous appendicitis; 3 = perforated appendicitis with abscess formation; 4 = appendicitis with diffuse peritonitis) were compared for patients with a normal WBC count (range, 3.8-10.9) versus those who had an elevated WBC count. A normal WBC count was seen in 11 per cent of patients (n = 209). There was no difference in age, temperature, gender, or severity of disease in the patients with a normal WBC count compared with those with an elevated WBC count (P > 0.05). The severity of disease of patients with a normal WBC count were: 1 = 58 per cent; 2 = 13 per cent; 3 = 7 per cent; and 4 = 22 per cent. For patients with an elevated WBC count the scores were: 1 = 57 per cent; 2 = 17 per cent; 3 = 13 per cent; and 4 = 14 per cent. The proportion of gangrenous and perforated appendicitis in the patients with a normal WBC count is the same as in the patients with an elevated WBC count.

MeSH terms

  • Abscess / diagnosis
  • Abscess / immunology
  • Abscess / pathology
  • Acute Disease
  • Adolescent
  • Adult
  • Appendicitis / diagnosis*
  • Appendicitis / immunology
  • Appendicitis / pathology
  • Appendix / pathology
  • Child
  • Diagnosis, Differential
  • Female
  • Gangrene / pathology
  • Humans
  • Intestinal Perforation / diagnosis
  • Intestinal Perforation / immunology
  • Intestinal Perforation / pathology
  • Length of Stay
  • Leukocyte Count*
  • Male
  • Prognosis
  • Reference Values
  • Rupture, Spontaneous
  • Sensitivity and Specificity