Syntheses of trans-5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-oxo-hexahydro-furo[3,2-b]pyrroles (pyrrolidine trans-lactams and trans-lactones): new pharmacophores for elastase inhibition

J Med Chem. 1998 Oct 8;41(21):3919-22. doi: 10.1021/jm981026s.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Azetidines / pharmacology
  • Humans
  • Lactams / chemical synthesis*
  • Lactams / pharmacology
  • Lactones / chemical synthesis*
  • Lactones / pharmacology
  • Leukocyte Elastase / antagonists & inhibitors*
  • Neutrophils / enzymology*
  • Piperazines / pharmacology
  • Serine Proteinase Inhibitors / chemical synthesis*
  • Serine Proteinase Inhibitors / pharmacology
  • Structure-Activity Relationship

Substances

  • Azetidines
  • Lactams
  • Lactones
  • Piperazines
  • Serine Proteinase Inhibitors
  • DMP 777
  • Leukocyte Elastase