Abstract
Background:
Enterobacter aerogenes is the fifth most frequent pathogen causing nosocomial infections. Several strains have developed multiple resistance by over-production of a natural cephalosporinase and by the presence of wide-spectrum betalactamases.
Case report:
A patient with chronic respiratory failure developed Enterobacter aerogenes pneumonia while under mechanical ventilation. The infection was successfully treated with a cefepime, sulbactam, gentamycin combination.
Discussion:
Choosing the optimum antibiotic therapy is a difficult task in many nosocomial infections. In certain cases, combining a betalactamase inhibitor with the appropriate antibiotic can improve bactericidal activity and provide successful cure.
MeSH terms
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use*
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Cefepime
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Cephalosporins / administration & dosage
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Cephalosporins / therapeutic use*
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Chronic Disease
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Cross Infection / etiology
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Drug Resistance, Microbial
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Drug Resistance, Multiple
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Drug Therapy, Combination / administration & dosage
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Drug Therapy, Combination / therapeutic use*
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Enterobacter*
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Enterobacteriaceae Infections / drug therapy*
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Gentamicins / administration & dosage
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Gentamicins / therapeutic use*
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Humans
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Male
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Middle Aged
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Pneumonia, Bacterial / drug therapy*
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Respiration, Artificial / adverse effects
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Respiratory Insufficiency / microbiology
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Sulbactam / administration & dosage
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Sulbactam / therapeutic use*
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Cephalosporins
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Gentamicins
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Cefepime
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Sulbactam