Abstract
The structure-function relationship of the neuronal nicotinic acetylcholine receptor is examined in the light of the allosteric concepts. Effects of site-directed mutagenesis as well as those caused by allosteric effector of the physiological and pharmacological receptor properties are discussed.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Allosteric Regulation
-
Animals
-
Humans
-
Models, Molecular
-
Mutagenesis, Site-Directed
-
Neurons / physiology*
-
Protein Conformation
-
Receptors, Nicotinic / chemistry*
-
Receptors, Nicotinic / metabolism*
-
Receptors, Nicotinic / ultrastructure
-
Recombinant Proteins / chemistry
-
Recombinant Proteins / metabolism
Substances
-
Receptors, Nicotinic
-
Recombinant Proteins