Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease

J Med Chem. 1998 Oct 22;41(22):4186-9. doi: 10.1021/jm9810452.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism
  • Alzheimer Disease / drug therapy*
  • Binding Sites
  • Butyrylcholinesterase / metabolism
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / metabolism
  • Cholinesterase Inhibitors / pharmacology*
  • Erythrocytes / enzymology
  • Humans
  • Kinetics
  • Ligands
  • Models, Molecular
  • Polyamines / chemistry
  • Polyamines / metabolism
  • Polyamines / pharmacology*
  • Receptor, Muscarinic M2
  • Receptors, Muscarinic / metabolism
  • Structure-Activity Relationship

Substances

  • Cholinesterase Inhibitors
  • Ligands
  • Polyamines
  • Receptor, Muscarinic M2
  • Receptors, Muscarinic
  • Acetylcholinesterase
  • Butyrylcholinesterase