Drugs causing dyslipoproteinemia

Endocrinol Metab Clin North Am. 1998 Sep;27(3):677-97. doi: 10.1016/s0889-8529(05)70033-5.

Abstract

Diuretics and beta-blockers have a strong tendency to affect serum lipids adversely, whereas the peripherally acting alpha-blocking agents consistently result in beneficial effects. Most of the other antihypertensive agents (calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists, and drugs that act centrally) are lipid neutral. The effect of steroid hormones varies with the drug, dose, and route of administration. In general, androgens lower HDL-C and have a variable effect on LDL-C. The effects of progestins vary greatly depending on their androgenicity, and estrogens are beneficial except when hypertriglyceridemia occurs with oral estrogens. Glucocorticoids raise HDL-C and may also increase triglycerides and LDL-C. Retinoids increase triglycerides and LDL-C and also reduce HDL-C. Interferons can cause hypertriglyceridemia. Following organ transplantation, a dyslipidemia often ensues. This is caused in part by the medications used to prevent rejection (glucocorticoids, cyclosporine, and FK-506) and requires close attention and, in some patients, drug therapy to prevent coronary artery disease.

Publication types

  • Review

MeSH terms

  • Antihypertensive Agents / adverse effects
  • Humans
  • Hyperlipoproteinemias / chemically induced*
  • Immunosuppressive Agents / adverse effects
  • Parenteral Nutrition / adverse effects
  • Retinoids / adverse effects
  • Steroids / adverse effects

Substances

  • Antihypertensive Agents
  • Immunosuppressive Agents
  • Retinoids
  • Steroids