Abstract
In mouse pancreatic islets, whether in situ or transplanted to kidney, nerve fibers and a few perikarya expressed NPY-like immunoreactivity (NPY-LI). In 4-5 day old grafts, NPY-LI coexisted with VIP-LI in randomly distributed nerve fibers. By 2-52 weeks, NPY mainly co-existed with tyrosine hydroxylase in fibers emanating from the kidney parenchyma. Radioimmunoassays indicated that the NPY levels increased with time, while those of VIP decreased. The study shows that NPY is primarily present in the intrinsic VIP-ergic innervation of islet grafts but later is mainly a constituent of the ingrowing sympathetic innervation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / analysis
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Animals
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Immunohistochemistry
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Islets of Langerhans / chemistry
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Islets of Langerhans / cytology
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Islets of Langerhans / innervation*
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Islets of Langerhans Transplantation*
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Kidney / blood supply
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Kidney / chemistry
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Kidney / innervation
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Mice
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Mice, Inbred C57BL
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Nerve Fibers / chemistry
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Neurons / chemistry*
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Neuropeptide Y / analysis*
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Pancreas / chemistry
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Pancreas / cytology
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Pancreas / innervation
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Radioimmunoassay
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Time Factors
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Tyrosine 3-Monooxygenase / analysis
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Vasoactive Intestinal Peptide / analysis
Substances
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Neuropeptide Y
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Vasoactive Intestinal Peptide
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Tyrosine 3-Monooxygenase
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Acetylcholinesterase