Abstract
We report on an elderly woman suffering from an acutely bleeding duodenal ulcer. Apart from old age and a history of gastrointestinal ulcer there were no risk factors detectable. However, clinical examination revealed that the patient had put a diclofenac hydroxyethylpyrrolidine plaster, which had been prescribed for lower back pain, inadvertently on a large ulcus cruris. The diclofenac serum concentration was 80 mu/l corresponding to a therapeutic serum level. This case demonstrates that false application of new pharmaceutical formulation may lead to inadvertent side-effects.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Administration, Topical
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Aged
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Aged, 80 and over
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics
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Back Pain / blood
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Back Pain / drug therapy
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Bandages
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Diclofenac / administration & dosage
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Diclofenac / adverse effects
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Diclofenac / analogs & derivatives*
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Diclofenac / pharmacokinetics
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Duodenal Ulcer / blood
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Duodenal Ulcer / chemically induced*
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Duodenal Ulcer / pathology
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Female
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Humans
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Peptic Ulcer Hemorrhage / blood
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Peptic Ulcer Hemorrhage / chemically induced*
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Peptic Ulcer Hemorrhage / pathology
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Varicose Ulcer / blood
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Varicose Ulcer / drug therapy*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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diclofenac hydroxyethylpyrrolidine
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Diclofenac