Abstract
A dihydroampicillin (3) and a dihydrocephalexin (4) have been synthesized by condensing alpha-(cyclohexa-1, 3-dienyl)glycyl chloride with 6-aminopenicillanic acid (1) and 7-deacetoxycephalosporanic acid (2) respectively. The two antibiotics obtained show enhanced antimicrobial activity towards certain bacterial strains compared with ampicillin and cephalexin.
MeSH terms
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Ampicillin / analogs & derivatives*
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Ampicillin / chemical synthesis
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Ampicillin / pharmacology
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Bacteria / drug effects*
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Cephalexin / chemical synthesis*
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Cephalexin / pharmacology
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Cephalosporins / chemical synthesis*
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Cephalosporins / pharmacology
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Microbial Sensitivity Tests
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Penicillins / chemical synthesis*
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Penicillins / pharmacology
Substances
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Cephalosporins
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Penicillins
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epicillin
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Ampicillin
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Cephalexin