Activity of HMR 3647 compared to those of five agents against Haemophilus influenzae and moraxella catarrhalis by MIC determination and time-kill assay

Antimicrob Agents Chemother. 1998 Nov;42(11):3032-4. doi: 10.1128/AAC.42.11.3032.

Abstract

The microdilution MICs of HMR 3647, erythromycin A, azithromycin, clarithromycin, roxithromycin, and pristinamycin against 50/90% of 249 Haemophilus influenzae and 50 Moraxella catarrhalis isolates were 2/4, 0.06/0.125; 8/16, 0.25/0.25; 2/4, 0.06/0.125; 16/16, 0.25/0.25; 32/>32, 1/2; and 2/4, 0.5/0.5 microg/ml. Azithromycin was bactericidal against all 10 H. influenzae and 3 of 5 M. catarrhalis isolates and HMR 3647, erythromycin A, clarithromycin, roxithromycin, and pristinamycin were bacteriostatic, against all 15 strains after 24 h at the MIC.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Culture Media
  • Haemophilus influenzae / drug effects*
  • Humans
  • Ketolides*
  • Macrolides*
  • Microbial Sensitivity Tests
  • Moraxella catarrhalis / drug effects*

Substances

  • Anti-Bacterial Agents
  • Culture Media
  • Ketolides
  • Macrolides
  • telithromycin