Abstract
We performed human leukocyte antigen (HLA) and human platelet antigen (HPA) in patients with Kami-kihi-to-responsive idiopathic thrombocytopenic purpura. The HLA-A2, A61 and Cw1 were significantly increased in responders compared with nonresponders, as were HLA DRB1 *0901, DRB1 *1502, and DPB1 *0501. In contrast, HLA DPB1 *0201 and DPB1 *0901 were significantly decreased in responders. The a/b genotype of HPA-2 and a/a genotype of HPA-3 were markedly increased in nonresponders, and anti-GPIb antibody was also increased. These results suggest that HLA, HPA, and anti-GP antibody studies may predict the response of idiopathic thrombocytopenic purpura to Kami-kihi-to.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Human Platelet / classification*
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Antigens, Human Platelet / genetics
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Drugs, Chinese Herbal / therapeutic use*
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Female
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HLA Antigens / classification*
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HLA Antigens / genetics
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HLA-A2 Antigen / classification
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HLA-A2 Antigen / genetics
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HLA-B Antigens / classification
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HLA-B Antigens / genetics
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HLA-C Antigens / classification
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HLA-C Antigens / genetics
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HLA-DR Antigens / classification
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HLA-DR Antigens / genetics
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HLA-DRB1 Chains
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Histocompatibility Testing
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Humans
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Male
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Purpura, Thrombocytopenic, Idiopathic / drug therapy
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Purpura, Thrombocytopenic, Idiopathic / immunology*
Substances
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Antigens, Human Platelet
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Drugs, Chinese Herbal
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HLA Antigens
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HLA-A2 Antigen
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HLA-B Antigens
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HLA-B61 antigen
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HLA-C Antigens
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HLA-DR Antigens
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HLA-DRB1 Chains