CT angiography has become an effective noninvasive imaging modality for evaluating the renal vasculature. The current clinical applications for CT angiography and three-dimensional (3D) imaging related to the kidneys and renal vasculature include evaluation of renal artery stenosis, renal diseases related to aortic diseases, living-related renal donor candidates, and preoperative evaluation of renal masses for possible nephron sparing surgeries. Imaging parameters need to be individually prescribed for renal CT angiography depending on the diagnostic goal of the examination. Methods for optimizing spiral CT protocols including patient preparation, contrast administration, image acquisition parameters, and image reconstruction will be covered.