Abstract
This paper reports on the physical and chemical characteristics of agents isolated from serum samples of patients presenting with epidemic neuropathy. The behaviour of isolated enteroviruses was as described for such viruses. Mild cytopathogenic effects-producing agents behaved in a variable form regarding sensitivity to chloroform; on the other hand they were neither sensitive to phosphonoacetic acid (PAA) nor to guanidine hydrochloride (GHC1) and grew in cells previously treated with bromodeoxyuridine (BDUR). These results suggest the presence of agents resembling enteroviruses and enveloped viruses. Further studies for the characterization of such agents need to be performed.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyclovir / pharmacology
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Antiviral Agents / pharmacology
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Bromodeoxyuridine / pharmacology
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Chemical Phenomena
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Chemistry, Physical
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Cuba / epidemiology
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Disease Outbreaks*
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Enterovirus / chemistry*
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Enterovirus / drug effects
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Enterovirus / isolation & purification
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Guanidine / pharmacology
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Humans
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Hydrogen-Ion Concentration
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Optic Neuritis / epidemiology
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Optic Neuritis / virology*
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Peripheral Nervous System Diseases / epidemiology
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Peripheral Nervous System Diseases / virology*
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Phosphonoacetic Acid / pharmacology
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Temperature
Substances
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Antiviral Agents
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Bromodeoxyuridine
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Guanidine
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Phosphonoacetic Acid
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Acyclovir